Dr. Michael D.Grant, M.D., F.A.C.S.
BREAST CANCER TERMS
Atypical Hyperplasia- Cells that are abnormal and increased in number. This is not a malignant diagnosis.
Axilla- The underarm area
Aromatase Inhibitor (Arimidex, Femara, Aromasin)- anti-estrogen pill used to treat postmenopausal women who have estrogen and/or progesterone receptor positive invasive cancer
Aspiration- The withdrawal of fluid or tissue with a small needle into a syringe
Biopsy- The removal of fluid or tissue for the purpose of examination under the microscope
Breast Cyst- Fluid filled sac in the breast tissue. When the fluid is aspirated, the cyst will be gone.
Calcifications- Small deposits of calcium in the breast tissue which can be seen on mammograms. These calcifications are determined by the radiologist to be in one of the following three categories:
Benign- requires routine follow up
Probably Benign- requires more frequent follow up
Indeterminate or Suspicious- requires biopsy
Carcinoma- A form of cancer that develops from epithelial cells that line many different organs of the body
(e.g. skin, uterus, ovaries, lungs, breast). Breast Cancer arises from the duct and lobule structures of the breast
Ductal Carcinoma in situ (DCIS)- early form of cancer which arises from the duct cells in the breast. This abnormal proliferation of cancer cells is confined to the walls of the duct structure and therefore, usually does not spread outside of the breast. It is also referred to as Noninvasive Duct Cell Carcinoma or Intraductal Carcinoma.
Lobular Carcinoma in situ (LCIS)- Also commonly referred to as Lobular Neoplasia, this is a premalignant condition that forms in the milk-producing lobules of the breast. This diagnosis places the patient at a higher risk of developing breast cancer in the future, but in itself, is not treated as a malignant condition.
Invasive (Infiltrating) Duct Cell Carcinoma- A form of cancer that arises from the duct cells in the breast but has spread to the surrounding tissues. This type of tumor is capable of spreading to other parts of the body.
Invasive (Infiltrating) Lobular Carcinoma- A form of cancer that arises from the milk-producing lobules of the breast, but has spread to the surround tissues. This type of tumor is capable of spreading to other parts of the body
Chemotherapy- Treatment with anti-cancer drugs Core Needle Biopsy- The use of a small core needle to take
samples of the abnormal tissue for microscopic evaluation
Fibroadenoma- Solid, benign breast mass
Fine Needle Aspiration- The use of a slender, fine needle to remove cells. These cells are put onto slides and sent to the pathologist for review under the microscope
Her2/neu Oncogene- A protein that is over-expressed on the surface of some breast cancer cells. These types of invasive breast cancers are sometimes treated with targeted monoclonal antibody drugs, such as trastuzumab (Herceptin), in combination with chemotherapy agents to significantly reduce cancer recurrence.
Hormone Therapy (Anti-hormonal Therapy, Endocrine Manipulation)- Treatment of cancer by removing, blocking or adding hormones
Lobular Carcinoma In Situ- A pre-malignant condition that forms in the lobules of the breast. This diagnosis puts the patient at higher risk for breast cancer in the future
Lumpectomy- Surgical removal of the malignant tumor and a border (margin) of normal breast tissue. This procedure is then followed by radiation therapy. Lumpectomy can also be referred to as partial mastectomy, segmental segmental resection, excisional biopsy, or breast conserving surgery
Lymphedema- Swelling in the arm or hand caused by the accumulation of excess fluid. This may occur from scarring of the lymphatic channels after surgery or radiation therapy
Lymph Nodes- Bean-shaped organs which act as filters of debris and cancer cells from the channels of the lymphatic system. These are located throughout the entire body and serve an immune function. The specific lymph nodes of interest related to breast cancer are located in the armpit (axillary), above the collar bone (supraclavicular), and underneath the breast bone (internal mammary)
Mammogram- X-ray of the breast
Mammogram showing normal breast tissue
Mammogram showing a malignant tumor
Margin- The area of tissue surrounding a tumor when it has been surgically removed
Metastasis- The spread of cancer cells from one part of the body to another part of the body through the lymphatic system or blood stream
Modified Radical Mastectomy- The removal of the majority (98%) of the breast tissue, the nipple, the areola, and two-thirds of the axillary lymph nodes
Needle Localization- A procedure in which a radiologist targets a breast tumor (or calcifications) with a thin guidewire. This allows the surgeon to accurately remove a nonpalpable tumor at the time of surgery. The localization procedure may be accomplished with sonographic, mammographic, stereotactic, or MRI guidance using a local anesthetic, usually on the day of surgery
Oncologist- A doctor who specializes in treating cancer
Medical Oncologist- doctor who treats cancer with chemotherapy and hormonal therapy
Radiation Oncologist- doctor who treats cancer with radiation therapy
Surgical Oncologist- doctor who treats cancer surgically
Palpable- Readily felt with the hands on examination
Partial Breast Irradiation (PBI)- "Investigational" Method of treating a patient with local radiation therapy after a lumpectomy. This technique only treats the lumpectomy site rather than the entire breast (standard treatment).
Pathology- The study and diagnosis of disease by examining samples of tissue underneath the microscope
Proliferation Index- A measure of how many cells within a specific tumor are dividing. This typically is used to guage the “aggressiveness” of a malignant tumor by performing a test called “Ki-67” or “MIB-1”
Prophylactic Mastectomy- Surgical removal of the breast that is not known to contain breast cancer
Prosthesis- An artificial breast form worn inside a bra after a mastectomy
Radiation Therapy- Treatment with high-energy radiation rays to kill cancer cells
Raloxifene (Evista)- an “anti-estrogen” pill used to improve bone density and as a “chemoprevention” agent to reduce the risk of developing breast cancer in some women who have not been diagnosed with the disease
Sentinel Lymph Node(s)- The first node(s) to which breast cancer cells are most likely to metastasize from the breast
Simple Mastectomy- The complete removal of the breast tissue, the nipple, and the areola
Skin-Sparing Mastectomy- The complete removal of the breast tissue while saving the majority of the outer skin envelope- usually combined with a reconstructive procedure for a better cosmetic result
Sonography- A procedure in which sound waves determine the density of a mass (solid or fluid-filled
Stereotactic Biopsy- The removal of a small amount of breast tissue with a technique that uses special mammographic views, a computer, and a needle to pinpoint a target area in the breast. This technique is usually utilized to biopsy calcifications or other tiny abnormalities that can only be detected mammographically.
Tamoxifen (Nolvadex)– an "anti-estrogen" pill often given to slow or stop tumor growth. It is commonly used for treatment of patients with breast cancers that express estrogen and/or progesterone receptor activity. Tamoxifen is also used as a "chemoprevention" agent to reduce the risk of developing breast cancer in some women who have not been diagnosed with the disease.